Merkel Cell Carcinoma: Epidemiology, Target, and Therapy
نویسندگان
چکیده
منابع مشابه
Survivin is a therapeutic target in Merkel cell carcinoma.
Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). By comparing digital transcriptome subtraction deep-sequencing profiles, we found that transcripts of the cellular survivin oncoprotein [BIRC5a (baculoviral inhibitor of apoptosis repeat-containing 5)] were up-regulated sevenfold in virus-positive compared to virus-negative MCC tumors. Knockdown ...
متن کاملMolecular Imaging and Therapy of Merkel Cell Carcinoma
Several molecular imaging modalities have been evaluated in the management of Merkel cell carcinoma (MCC), a rare and aggressive tumor with a high tendency to metastasize. Continuous progress in the field of molecular imaging might improve management in these patients. The authors review the current modalities and their impact on MCC in this brief review article.
متن کاملMerkel cell polyomavirus and cutaneous Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine skin cancer of elderly patients. Generally, it originates from Merkel cells of the basal layer of the epidermis characterized by typical neuroendocrine granules (neuron-specific enolase; NSE+) and keratin filament (cytokeratin-20; CK20). Its incidence has been increasing in the last two decades, likely because of improved ability t...
متن کاملDigital Merkel cell carcinoma.
Merkel cell carcinoma (MCC) is a rare and biologically aggressive neuroendocrine tumour of the skin. Recent analysis of a surveillance, epidemiology and end results program has shown a statistically significant increase of 8% per year in the age-adjusted rates for MCC of the skin over the past 15 years. MCC commonly presents as a painless, rapidly growing, single red or purple cutaneous nodule....
متن کاملMerkel cell carcinoma
BACKGROUND Merkel cell carcinoma (MCC) is an unusual primary neuroendocrine carcinoma of the skin. MCC is a fatal disease, and patients have a poor chance of survival. Moreover, MCC lacks distinguishing clinical features, and thus by the time the diagnosis is made, the tumour usually have metastasized. MCC mainly affects sun-exposed areas of elderly persons. Half of the tumours are located in t...
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ژورنال
عنوان ژورنال: Current Dermatology Reports
سال: 2014
ISSN: 2162-4933
DOI: 10.1007/s13671-014-0068-z